NCE delay for Amarin takes a bite out of its share price; Actelion scales back layoff plans; Takeda completes Russian drug plant;

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> Shares of Amarin ($AMRN) took a hit overnight after the company filed papers noting that the FDA had yet to decide whether its industrial-strength fish oil product Vascepa warranted approval as a new chemical entity, a classification that carries 5 years of marketing exclusivity with it. The lengthy delay on the NCE ruling caused considerable hooting on Twitter as analysts like Adam Feuerstein at TheStreet concluded that Amarin is likely to wind up without the NCE stamp, leaving the company with only three years of exclusivity and a quick onslaught of generic competition. Amarin shares are down 5% this morning. Story

> After negotiating with labor groups Switzerland's Actelion has reduced the number of jobs it plans to cut from a maximum of 70 down to 40. Actelion has been streamlining operations following its R&D success with a next-gen therapeutic. Story

> Racing to snag a leading position in the growing Russian drug market, Japan's Takeda has just completed a $96 million manufacturing facility in an effort to build local production capability. Story

> Sunesis Pharmaceuticals says it plans to implement a one-time, 225-patient sample size increase to its Phase III study of vosaroxin in acute myeloid leukemia, bringing target enrollment to 675 patients. Release

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And Finally… Those electronic devices we use at night can reduce levels of melatonin and interfere with sleep schedules, according to a new study. Story