Isis nabs $10M milestone; AstraZeneca/Bristol-Myers team wins priority review status;

 @FierceBiotech: ICYMI: NIH lays out effects of sequestration on biomedical research. Article | Follow @FierceBiotech

 @JohnCFierce: Aveo slashes 140 jobs, halts R&D work related to doomed FDA drug application. News | Follow @JohnCFierce

 @RyanMFierce: GenoSpace joins growing alliance for sharing translational research data. Article | Follow @RyanMFierce

 @EmilyMFierce: More New Yorkers skipping vaccines on religious grounds. Story | Follow @EmilyMFierce

> Isis Pharmaceuticals ($ISIS) nabbed a $10 million milestone from AstraZeneca ($AZN). Story

> FDA has granted priority review status to metreleptin, a metabolic drug being developed by Bristol-Myers Squibb ($BMY) and AstraZeneca. Report

> Cambridge, MA-based Proteostasis Therapeutics has received a grant from the Michael J. Fox Foundation to fund preclinical research on Parkinson's disease drugs by enhancing the clearance of a-synuclein. Release

> Avanir Pharmaceuticals ($AVNR) says the FDA agreed to an expedited development pathway for AVP-786, requiring only a limited pre-clinical package as part of the IND. Release

Medical Device News

 @FierceMedDev: NeuroMetrix preferred stock placement pulls in $5M. Item | Follow @FierceMedDev

 @DamianFierce: Amid efficacy worries from the FDA, Abbott posted more positive results for MitralClip. Report | Follow @DamianFierce

 @MarkHFierce: Our latest special report - a closer look at six device and Dx startups making waves. Feature | Follow @MarkHFierce

> Bard's drug coated balloon begins 'below-the-knee' PAD trial. Story

> Baxter raising $3.5B to close Gambro megadeal. News

> Valeritas hauls in $100M for insulin device. Report

> Georgia Tech team creates superpaper with Dx potential. DxExtra

Pharma News

 @FiercePharma: Swedish drugmaker Meda says it's not in buyout talks. Sun Pharma had reportedly been eyeing a deal. More | Follow @FiercePharma

 @EricPFierce: FDA tells Novartis in warning letter it doesn't like what it sees at Austria plant, particles in vials. More | Follow @EricPFierce

 @CarlyHFierce: India's officials have been tough on Big Pharma but may now resurrect Pfizer's Sutent patent. Article | Follow @CarlyHFierce

> India's Cadila scouts Big Pharma partners to launch new diabetes drug abroad. News

> Sky-high drug prices will force change in cancer care, experts say. Story

> Novartis' Sandoz unit stumbles again. Report

> Meda responds to Sun buyout reports with firm 'no deal.' Article

Drug Delivery News

 @MichaelGFierce: Novel oral drugs spur big investments for Akebia, Protagonist. Article | Follow @MichaelGFierce

> Hydrogels deliver immuno drugs to transplanted hands. Story

> Janssen Labs-based Arcturus gets $1.3M boost for RNAi delivery tech. Item

> In study, nasal spray cuts addictive binge eating in obese patients. More

> Nanoparticles release chemo when activated with red light. Story

And Finally… It turns out that one of the best ways to prevent your skin from aging is by regularly using sunscreen. Story

Suggested Articles

A patient has died in the global study of AstraZeneca’s COVID-19 vaccine, Brazil’s health authority, Anvisa, announced on Wednesday.

MyoKardia wasn’t looking for a buyout when it started discussing potential partnerships with Bristol Myers Squibb last year.

The patient was hospitalized with febrile neutropenia in the weeks after receiving the drug and died 52 days post-treatment with the CAR-T therapy.