@FierceBiotech: Shares of Prana collapse after long-shot Alzheimer's study flops. News | Follow @FierceBiotech
@JohnCFierce: GlaxoSmithKline's darapladib team finds hope in a PhIII bomb $GSK. Editor's Corner | Follow @JohnCFierce
@DamianFierce: In case you weren't in the mood for ACC14 this weekend, Amgen's PCSK9 drug played a starring role. More | Follow @DamianFierce
@EmilyMFierce: Ancient virus DNA gives stem cells the power to transform. Story via National Geographic | Follow @EmilyMFierce
> GlaxoSmithKline ($GSK) is throwing in the towel on its campaign to get Votrient approved for advanced ovarian cancer. The drug giant is pulling its application in Europe after concluding that the data didn't paint a sufficiently positive portrait of overall survival benefits for patients--despite an improvement seen in progress-free survival. And the pharma giant has slammed the brakes on filing applications in other countries as well. "We believe that, in spite of the improvement in progression free survival observed in our Phase III study, the totality of the evidence including these more mature OS data, do not support an overall positive benefit-risk for Votrient in this indication," says GSK's oncology chief Rafael Amado. Release
> Cerulean Pharma has laid out terms for its upcoming IPO. The biotech plans to raise about $60 million from the share of 5 million shares for $11 to $13 apiece. Leerink Partners is the bookrunner. Story
> Johnson & Johnson ($JNJ) says it will test Xarelto in three new Phase III studies involving about 11,000 patients. Investigators will study the drug's effect on deep vein thrombosis and pulmonary embolism. Release
Medical Device News
@FierceMedDev: Abbott gained approval for a new PAD stent it acquired last July in a $310 M&A deal. Item | Follow @FierceMedDev
@MarkHFierce: Johnson & Johnson has agreed to sell its Ortho Clinical Diagnostics arm to Carlyle for more than $4B. Story | Follow @MarkHFierce
@MichaelGFierce: ICYMI: NeuroSigma brings on two Amgen execs to bolster its finance team. Item | Follow @MichaelGFierce
@EmilyWFierce: In a regulatory overhaul, Chinese authorities pass new rules governing medical devices. News | Follow @EmilyWFierce
> Medtronic commits to renal denervation as company details disappointing trial results. Story
> First head-to-head trial finds Edwards' TAVR superior to Medtronic's. More
Pharma News
@FiercePharma: Top-read over the weekend - two special reports: The 10 best-selling drugs of 2013. Report. and The top 10 pharma companies by 2013 revenue. Report | Follow @FiercePharma
@TracyStaton: RT: Today is the first time in my 10 year data that larger cap biotech is trading at the same PE as US. | Follow @TracyStaton
@EricPFierce: FDA 's Woodcock throws cold water on research that found foreign-made generics of Lipitor tainted. Article | Follow @EricPFierce
@CarlyHFierce: Regeneron clears roadblock for new plant in Irish tax haven. Story | Follow @CarlyHFierce
> Massachusetts bans Zogenix's controversial new painkiller Zohydro. News
> FTC aiming for $1B pay-for-delay patent settlement this year. More
> Biogen hemophilia nod puts Baxter's to-be-spun-off biopharma unit on notice. Article
CRO News
> Icon is buying Aptiv with a focus on adaptive trials. News
> Covance dials up its biologics offerings, adding 100 new jobs. Story
> Quintiles signs on to help BioDelivery get its anti-addiction drug out the door. Story
> Rho inks a federal bioterror pact with $100M on the line. News
> NephroGenex picks Medpace for kidney disease Phase III. Story
> BioClinica bags $30M in Big Pharma deals. Brief
Biotech IT News
> GSK teams up to apply Big Data to target validation. Story
> Illumina CEO sees bioinformatics as key to completing sequencing puzzle. Article
> Report: IMS Health aiming to raise $1.4B in upcoming IPO. News
> Busy week at Intel bolsters its presence in life sciences. Story
> NIH looking to research community for data and metadata standards. Article
> Duke setting up precision medicine center in Genome Institute reshuffle. Brief