For the Treatment and Prevention of Venous Thromboembolism, Bayer/Ortho-McNeil’s Xarelto Will Earn Peak-Year Sales of $500

However, Xarelto’s Overall Uptake Could Be Constrained By a Perception of an Increased Risk of Bleeding in Patients, According to Findings from Decision Resources

BURLINGTON, Mass.--(BUSINESS WIRE)-- Decision Resources, one of the world’s leading research and advisory firms for pharmaceutical and healthcare issues, finds that, following its expected launch in the United States in 2012 for venous thromboembolism (VTE) prophylaxis in medically ill patients, the overall uptake of Bayer/Ortho-McNeil’s Xarelto (rivaroxaban) could be constrained in this indication by a perception of an increased risk of bleeding. Nonetheless Xarelto will achieve blockbuster potential in the world’s major pharmaceutical markets.

The Pharmacor 2011 findings from the topic entitled Venous Thromboembolism reveal that, following the recently released MAGELLAN clinical trial data that demonstrated Xarelto’s non-inferiority over Sanofi-Aventis’s Lovenox (the current standard of care for VTE) in the first phase of the trial, Decision Resources forecasts Xarelto will earn peak-year VTE sales of $500 million to $1 billion in the United States, France, Germany, Italy, Spain, United Kingdom and Japan.

“We expect that the MAGELLAN trial subgroup analyses will reveal patient groups where Xarelto has a favorable risk-benefit profile,” said Decision Resources Analyst Matthew Killeen, Ph.D. “Although these subgroup analyses will enable this oral factor Xa inhibitor to secure approval in the United States for the potentially lucrative indication of VTE primary prophylaxis in medically ill patients, a perception of an increased risk of bleeding could constrain its uptake.”

The Pharmacor 2011 findings also reveal that Decision Resources expects Bristol-Myers Squibb/Pfizer’s Eliquis (apixaban) to perform well in the ADOPT clinical trial, owing to its bleeding profile seen in other clinical studies and its lower level of renal clearance as compared to other novel oral anticoagulants.

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Decision Resources, Inc.
Christopher Comfort, 781-993-2597
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