Cambridge, MA-based Ariad Pharmaceuticals ($ARIA) is axing about 90 staffers--25% of its total workforce--in an ongoing restructuring of the business. The biotech is also reviewing its R&D portfolio and other aspects of the business, saying it plans to unveil more changes in Q2. Ariad says it is concentrating efforts around its once-suspended cancer drug Iclusig as well as the late-stage drug brigantinib. Brigantinib, its only other clinical asset, is in pivotal studies for non-small cell lung cancer. Ariad laid off 40% of its staff in 2013 when it was forced to yank its leukemia drug off the market. Release