Agenus' herpes vaccine shows promise in Phase II; 4d Pharma raises $36.6M;

@FierceBiotech: Polaris preps for a $400M fund to back a new wave of biotechs. More | Follow @FierceBiotech

@JohnCFierce: Biotech vets target $43M round to debut new antifungal venture. Story | Follow @JohnCFierce

@DamianFierce: We need to commission an inversion graphic for future stories. Article | Follow @DamianFierce

@EmilyMFierce: Gives a new meaning to YOLO: The Higgs Boson should have crushed the universe. More | Follow @EmilyMFierce

> In a Phase II trial, Agenus' ($AGEN) herpes vaccine led to an immune responses in more than half of patients and notched a statistically significant 75% reduction in viral load in that population. More

> The U.K.'s 4d Pharma, which recently went public, raised £21.5 million ($36.6 million) in a stock offering. News

> The recently IPO'd ZS Pharma ($ZSPH) has kicked off enrollment in its Phase III trial of ZS-9, an investigational treatment for the kidney disease hyperkalemia. Item

Medical Device News

@FierceMedDev: Check out our newest special report: Top 10 med tech R&D budgets. Read | Follow @FierceMedDev

@StacyALawrence: Newly public Inogen gains on FDA clearance for home oxygen device. Story | Follow @StacyALawrence

@MichaelGFierce: Intersect ENT files for $80M IPO to support steroid-delivering sinus implants. More via FierceDrugDelivery | Follow @MichaelGFierce

@EmilyWFierce: Ultrasound therapy outfit rakes in $2M for wearable chronic pain device. Story | Follow @EmilyWFierce

> Danaher demurs on M&A, looks to China, Brazil and Russia. Piece

> $125M IPO planned for former BMS medical imaging unit. News

Pharma News

@FiercePharma: Special: The top 5 vaccines by 2020. Report | Follow @FiercePharma

@TracyStaton: Here's @JohnCFierce's take on the Vertex VX-809/Kalydeco PhIII, including interview with CEO Jeff Leiden. Story | Follow @TracyStaton

@EricPFierce: Actavis says growing production at plant in Malta called for new warehouse. More | Follow @EricPFierce

@CarlyHFierce: Here's this week's issue of FierceVaccines. Hint: It's a good one. Issue | Follow @CarlyHFierce

> Eli Lilly's anti-takeover superpower? A shield forged by Indiana lawmakers. Story

> Biogen MS blockbuster Tecfidera earns high marks for safety. Article

> Reuters: Valeant supporter Paulson grabs 6 million-plus Allergan shares. More

> After 4-year Benicar review, FDA slaps aside heart-risk worries. News

Vaccines News

> Italian officials probe Novartis for possible flu vaccine pricing fraud. Story

> FDA slaps Glaxo with warning letter for FluLaval plant. More

> CDC committee recommends AZ's FluMist over flu shot in children. Article

> The top 5 vaccines by 2020. Report

> Feds charge researcher in HIV vaccine fraud case. More

> Reuters: Sanofi plans to put dengue program into separate unit. News

Pharma Manufacturing News

> FDA finds contamination issues at GSK vax plant. More

> India production expert urges excellence from drugmakers. Story

> New Indian government looks to help small players finance upgrades. Article

> Sanofi buys Dubai's Globalpharma to produce generics in the Middle East. News

> Actavis opens $18M warehouse on Malta. Report