Acadia postpones NDA for 'breakthrough' Parkinson's drug; Alchemia CEO exits;

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> Acadia disappointed investors with the news that it will delay its planned NDA for the Parkinson's drug pimavanserin (Nuplazid). The biotech--which recently won 'breakthrough' status for the treatment--now plans to file in the first quarter of 2015. Its shares were down 3% this morning. Release

> Australia's Alchemia says CEO Thomas Liquard has left the company and will be temporarily replaced by non-executive chairman Tracie Ramsdale. Release

Medical Device News

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> Thync rolling out wearable, noninvasive device to elevate mood with fresh infusion of cash in tow. More

> Medtronic makes concessions to European regulator in bid to close Covidien deal. News

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Pharma News

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> Merck's head-to-head Vytorin trial might be surprisingly flattering. More

Biotech Research News

> Small human study will test a new approach to fighting diabetes. More

> Research team points to Sestrin 3 as a potential new target in diabetes. Article

> Harvard investigators prep an animal study of CRISPR Cas tech for HIV. Story

> Swiss team at ETH spotlights potential of a new antibiotic found in nature. More

> Genentech R&D team fixes a flawed approach to Alzheimer's. Report

Pharma Manufacturing News

> Cadila API plant slapped for faulty follow-up on stinking APIs. Article

> Dr. Reddy's, Endo benefit from Ranbaxy manufacturing shortfalls. Item

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> Dendreon, done in by expensive, complex manufacturing, files for bankruptcy. Story

> Fresenius expansion plans in Russia sidelined by political turmoil. Article

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