Drugmakers face an uphill battle with payers for some meds. Dr. Deborah Dunsire, CEO of Millennium Pharmaceuticals, is taking seriously issues related to reimbursement on new drugs. "The thing that is foremost on my mind is that this industry has to get really serious about economic benefit to the system as well as innovation," Dunsire says. "We haven't really grasped and bitten on that yet. I think we've got really smart people in the industry who can make that happen."