Scientist - In Vivo Pharmacology - EMD Serono

Position Description

About the Company

EMD Serono, Inc., an affiliate of Merck KGaA, Darmstadt, Germany, is a leader in the US biopharmaceutical arena, integrating cutting-edge science with unparalleled patient support systems to improve people’s lives. The company has strong market positions in neurodegenerative diseases, MS and endocrinology. EMD Serono is also a leader in fertility treatments. With a clear focus on the patient and a leadership presence in the biopharmaceutical industry, EMD Serono’s US footprint continues to grow, with more than 1000 employees around the country and fully integrated commercial, clinical and research operations in the company’s home state of Massachusetts.

Description

EMD Serono is currently looking for a motivated and talented scientist to expand the Neurodegenerative Diseases group in Cambridge, MA.

It is anticipated that this position will move to Billerica in 2011.

The purpose of the position is to conduct experiments under routine supervision using disease-relevant in vitro models to support drug discovery project teams for the treatment of Parkinson’s disease.

KEY TASKS & RESPONSIBILITIES

This individual will be an integral part of a team that will use molecular, genetic, imaging and biochemical techniques to investigate the molecular mechanisms of nervous system disorders and to participate in drug discovery projects. A background in neurodegenerative or psychiatric models related to Parkinson’s disease is desirable.

The incumbent is expected to contribute to studies for multiple projects and to present his/her research internally in group settings. The candidate must have the ability to work collaboratively with others and independently perform and analyze in vitro experiments in line with assignments from his/her supervisor.

Specific responsibilities include:

• Generates and characterizes stable cell lines for the development of disease-relevant cell models
• Prepares and maintains primary neuronal cultures (including dissection)
• Develops cell-free and cell-based assays for the identification of lead molecules and for mechanism of action studies
• Performs data analysis, interpretation of results and trouble-shooting
• Prepares written documents for internal reports
• Gives data presentation to research teams
• Expected to be familiar with technical and scientific literature pertaining to assigned project
• Supports general laboratory maintenance and safety

EDUCATION/ LANGUAGES

• B.S./B.A. in biological sciences with 2 – 5+ years related industry/research experience or M.S. with 2+ years related industry/research experience. Degree with an emphasis on neurobiology is preferred.
• Verbal and written fluency in English is required

• Proficiency in cell culturing and aseptic techniques
• Experience in working with DNA and RNA (e.g. cloning, purification, PCR)
• Experience with protein expression and analysis (e.g. cell transfection, Western blot, immunocytochemistry, subcellular fractionation)
• Familiarity with multiple screening platforms (e.g. ELISA, fluorescence/luciferase-based assays) and use of plate readers
• Experience with evaluating drug effects in vitro
• High level of computer literacy (e.g. Excel, Vector NTI, Prism)

• Highly self-motivated, organized and detail-oriented
• High level of flexibility and adaptability to a changing environment
• Excellent oral and written communication skills.
• Must be able to work in a team.