PRIMARY ROLE:

To provide strategic planning & design input and implementation of health outcomes programs to support the go/no go decision of product candidates, pricing and reimbursement for Shire products across global markets.

To provide pharmacoeconomic and outcomes research guidance to the product/project development teams regarding drug development in order to maximize commercial opportunities for Shire products.

To liaise with key stakeholders in regional hub (Switzerland) and ensure communications between global and regions are effective and needs of both are addressed.

To identify, select, establish and manage a global network of contractors, consultants, and CROs to execute planned HEOR global deliverables.

RESPONSIBILITIES:

30%
Identify, evaluate, retain and oversee aglobal network consultants and contract organizations to execute the health outcomes work (studies, health technology assessments, and economic analyses). In particular, representing the HEOR function at team meetings, BU meetings, and meetings with senior management to ensure provision of HEOR outputs to support internal decision making during product development and commercialization to:
• Produce high-quality project deliverables to agreed timelines and budgets
• Develop and maintain a strong network of professional contacts
• Produce cost effectiveness model-based economic evaluations, budget impact analyses and burden of illness studies
• Support adaptation of economic models in accordance with local requirements/guidelines
• Prepare economic and product value strategy dossiers
• Contribute to reimbursement and HTA submission documentation
• perform prospective or retrospective database analyses

35%
Provision of prompt health economic assessments to support decisions on possible in-licensing of products made jointly with Commercial, BU, and R&D colleagues.

To ensure development of programs to support value proposition(s) for Shire products globally, including:
• Document unmet needs by demonstrating economic and humanistic burden of illness in
planned/approved indications for the products
• Contribute to the design, HEOR endpoint selection, reporting and analysis of clinical studies
• Support scientific content output (abstracts/manuscripts/posters) based on clinical studies ensuring publications support for HEOR analyses for products where available

Contribute to the development of Target Product Profiles (TPP) and Clinical Development Plans (CDP) as well as commercial strategies for identifying and supporting prospective or retrospective research to support sales and ensuring its execution

20%
Maintain awareness of global HEOR requirements, regulatory legislation, payor trends & requirements.

Research and perform critical analysis of medical and scientific evidence as the basis for disease management guidelines, P&T Committee actions, and pharmacoeconomic comparisons of therapies.

15%
Contribute to the development of Target Product Profiles (TPP) and Clinical Development Plans (CDP) as well as commercial strategies for identifying and supporting prospective or retrospective research to support sales and ensuring its execution.

REQUIREMENTS:

Master’s degree in Health Economics, Pharmacoeconomics, decision sciences (or similar) with 7 or more years experience in global pharmaceutical or medical device industry or PhD in Health Economics, Pharmacoeconomics, decision sciences (or similar) with at least 5 years experience.

Experience in interfacing with external scientific bodies & preference for experience with interactions
with reimbursement agencies in US and/or Europe.

ESSENTIAL SKILLS:
• Appropriate awareness of global drug development, health economics, pharmaceutical outcomes research.
• Experience in developing models (early and late stage development) to demonstrate the cost effectiveness of health technologies
• Excellent communication skills, influencing and negotiation skills
• Ability to work cross-functionally
• Self motivated and able to work independently

DESIRED SKILLS:
• Experience of preparing and making submissions European HTA agencies such as NICE or HAS and or preparation and submissions of AMCP dossiers in the USA
• Synthesis of data using Bayesian techniques

The incumbent has authority to propose strategies and to define the methodology for PE modeling and stand alone outcomes studies. Will also guide the value proposition development and provide input to PST/CDP for appropriate health outcomes endpoints in studies

Travel will be required (up to 25%). Experience and willingness to work in a global environment is essential.

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